![]() Endogenous cortisol is measured in 80 patients before and after the first training session. All patients perform six training sessions within 2 weeks. ![]() After baseline assessment, participants are randomly assigned to one of three computerized Go-NoGo-based inhibition training interventions (two alcohol-specific versions with different Go/NoGo ratios, or neutral control training) and one of two intervention times (morning/afternoon), resulting in six study arms. This is a double-blind, randomized controlled trial (RCT) with 246 inpatients with AUD participating. It also analyzes whether variations in inhibition difficulty and/or endogenous cortisol levels during training impact these effects. This study tests a computerized alcohol-specific inhibition training in a large clinical sample and investigates its effects on behavioral, experimental and neurophysiological outcomes. Complementary to traditional relapse prevention strategies, novel computerized training interventions aim to directly alter these processes. Most current neuroscientific conceptualizations of AUD focus on the imbalance between an enhanced automatic reaction to alcohol cues and impaired inhibition. To achieve higher therapy success rates, therapeutic interventions still need to be improved. Alcohol use disorder (AUD) leads to a significant individual and societal burden.
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